| Cat.No.: | EAb-2064 |
| Product Name: | RING1 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This antibody was raised against a peptide within the C-terminal region of human RING1. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 50 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:250 - 1:500 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | RING1 (Ring Finger Protein 1) constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0119 | Human RING1 Knockout Cell Line 1bp deletion | Inquiry |
| CL-0401 | Human RIF1 Knockout Cell Line 37bp insertion | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0178 | Human RIG-I/DDX58 peptide | Inquiry |
| ◆ Antibodies | ||
| EAb-1750 | RING1 Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1892 | RIZ1 (human recombinant) | Inquiry |
| Related Gene / Proteins | |||
| RIF1 | RIG-I | RING1 | RING1B |
| RIZ1 | |||
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