SETD7 / SET7 Polyclonal Antibody

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Cat.No.:  EAb-2058
Product Name:  SETD7 / SET7 Polyclonal Antibody
Antibody Type:  Polyclonal
Immunogen:  This antibody was raised against a peptide within human SETD7 / SET7.
Host:  Rabbit
Isotype:  IgG
Molecular Weight:  60 kDa
Purification:  Affinity Purified
Appearance:  Liquid
Formulation:  Purified IgG in PBS with 30% glycerol and 0.035% sodium azide.
Applications:  WB: 1:500 - 1:1,000 dilution ^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user.
Species Reactivity:  Human
Storage:  -20°C
Warning:  For Research Use Only! Not For Use in Humans.
Scientific Background:  SETD7 / SET7 (SET Domain Containing (Lysine Methyltransferase) 7) is a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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