| Cat.No.: | EAb-2057 |
| Product Name: | SATB1 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This SATB1 antibody was raised against a peptide within the N-terminal region of SATB1. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 105 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:500 - 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | SATB1 (Special AT-rich sequence-binding protein 1) is a chromosome-associated protein that binds to matrix attachment regions (MARs) of DNA at special AT-rich sequences and induces local chromatin-loop remodeling. SATB1 functions as both a chromatin organizer and transcription factor. It regulates gene expression and higher-order chromatin structure of multigene clusters. SATB1 acts as a docking site for several chromatin remodeling enzymes and recruits corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. It is required for the switching of fetal globin genes, plays a role in chromatin organization and nuclear architecture during apoptosis. It is a crucial factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis. SATB1 contributes to metastatic potential in breast cancer cells, directly upregulating metastasis-associated genes while downregulating tumor-suppressor genes. It is also required for the differentiation of embryonic stem cells through repression of ES pluripotency factors Nanog, Klf4, and Tbx3. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0034 | SALL1 Polyclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0058 | 3-Deazaadenosine | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0152 | Recombinant Human SAP30L 293 Cell Lysate | Inquiry |
| EL-0155 | Recombinant Human SAP30BP 293 Cell Lysate | Inquiry |
| EL-0164 | Recombinant Human SAP30 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| SAH | SALL1 | SALL4 | SAP130 |
| SAP145 | SAP18 | SAP30 | SAP30BP |
| SAP30L | SART3 | SATB1 | SATB2 |
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