| Cat.No.: | EAb-2014 |
| Product Name: | SNF5 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This SNF5 antibody was raised against a peptide sequence)(CDAEMEKKIRDQDRNTR in the C-terminus of SNF5. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 60 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified rabbit IgG in 70 mM Tris (pH 8), 105 mM NaCl, 32 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:500 - 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | SNF5 (Sucrose Non Fermenting 5, also called INI1, BAF47 and SMARCB1) is a tumor suppressor protein that is a component of the SWI/SNF chromatin-remodeling complex that regulates gene expression through alterations in chromatin structure. Alterations in chromatin structure facilitated by ATP-dependant chromatin remodeling machines are thought to enhance recognition and binding of trans-acting factors that bind DNA and regulate transcription. SNF5 signals through the p16INK4a pathway to negatively regulate cell cycle progression and mediate chromosome stability. Mutations in SNF5 are a cause of malignant rhabdoid tumors in children. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0784 | Swi2/SNF2 Polyclonal Antibody | Inquiry |
| EAb-0790 | SNFa/BRM Polyclonal Antibody | Inquiry |
| EAb-1821 | SNAI1 / Snail Monoclonal Antibody | Inquiry |
| EAb-1983 | SND1 Monoclonal Antibody | Inquiry |
| EAb-2014 | SNF5 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| SNAI1 | Snail | SND1 | SNF2 |
| SNF2L1 | SNF5 | SNFa | SNRP70 |
| SNRPG | |||
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