TIEG1 / KLF10 Polyclonal Antibody


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Cat.No.:  EAb-1934
Product Name:  TIEG1 / KLF10 Polyclonal Antibody
Antibody Type:  Polyclonal
Immunogen:  This TIEG1 / KLF10 antibody was raised against a peptide derived from human TIEG1 / KLF10.
Host:  Rabbit
Isotype:  IgG
Molecular Weight:  50 kDa
Purification:  Affinity Purified
Appearance:  Liquid
Formulation:  Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide.
Applications:  WB: 1:500 - 1:1,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user.
Species Reactivity:  Human
Storage:  -20°C
Warning:  For Research Use Only! Not For Use in Humans.
Scientific Background:  TIEG1 / KLF10 (Transforming growth factor β-inducible early gene 1, Kruppel-like factor 10) is a transcriptional regulator involved in the control of cell growth. KLF10 binds to Sp1 / GC rich DNA sequences and can activate or repress the transcription of a number of genes. KLF10 is especially important for osteoblast function, including bone mineralization and support of osteoclast differentiation. KLF10 is rapidly induced by TGFβ, bone morphogenetic protein, estrogen and epidermal growth factor. KLF10 plays a major role in TGFβ-mediated inhibition of cell proliferation and inflammation and induction of apoptosis.
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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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