| Cat.No.: | EAb-1918 |
| Product Name: | MMSET / WHSC1 Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This MMSET / WHSC1 antibody was raised against a recombinant protein corresponding to amino acids 1-647 of human MMSET-I. |
| Host: | Mouse |
| Isotype: | IgG2b |
| Molecular Weight: | 88 and 157 kDa |
| Purification: | Protein G Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | ChIP: 2 - 5 µg per ChIP; ChIP-Seq: 10 µg each; ICC/IF: 0.5 µg/ml dilution; WB^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | MMSET (Multiple Myeloma SET domain-containing protein) / WHSC1 (Wolf-Hirschhorn Syndrome Candidate 1; also known as NSD2, Nuclear Receptor binding SET domain protein 2; TRX5, Trithorax 5) is a SET domain-containing histone methyltransferase specific for lysine 36 of histone H3. The MMSET / WHSC1 gene is deleted in Wolf-Hirschhorn syndrome, a disorder characterized by developmental defects and mental retardation. In 15% of patients with Multiple Myeloma (MM), a chromosomal translocation leads to MMSET / WHSC1 gene being aberrantly placed under the control of the IgH intronic µ enhancer and expressed at very high levels. This event is apparently a key component in cellular transformation leading to MM. Reduction in MMSET / WHSC1 expression in a myeloma cell line suppressed its growth, suggesting a role for MMSET in maintaining the transformed state. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0127 | Recombinant Human WHSC1L1 293 Cell Lysate | Inquiry |
| EL-0128 | Recombinant Human WHSC1L1 293 Cell Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0222 | Human WHSC1L1 Knockout Cell Line 10bp deletion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0306 | Doxycycline (hyclate) | Inquiry |
| ◆ Antibodies | ||
| EAb-0890 | WHSC1L1 Polyclonal Antibody, HRP Conjugated | Inquiry |
| Related Gene / Proteins | |||
| MMP | MMSET | WHSC1 | WHSC1L1 |
USA
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