| Cat.No.: | EAb-1917 |
| Product Name: | MLL / HRX Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This MLL / HRX antibody was raised against a recombinant protein corresponding to amino acids 161-356 of mouse MLL. |
| Host: | Mouse |
| Isotype: | IgG1 |
| Molecular Weight: | 440 kDa |
| Purification: | Protein G Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | ChIP; IP; WB |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | MLL (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)), also known as Histone-lysine N-methyltransferase HRX, is a SET-domain containing histone methyltransferase specific for lysine 4 of histone H3. It serves as a transcriptional activator for many target genes, including several HOX genes. MLL is a frequent target for translocations in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and mixed lineage leukemia (MLL). A key feature of MLL fusion proteins is their ability to efficiently transform hematopoietic cells into leukemia stem cells. Leukemogenic MLL translocations encode MLL fusion proteins that have lost H3 Lys4 methyltransferase activity. MLL is found in a complex of proteins that includes ASH2L, WDR5, DPY30 and RBBP5. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0170 | MI-3 | Inquiry |
| BSM-0187 | OICR-9429 | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0172 | Human KMT2C / MLL3 peptide | Inquiry |
| ◆ Research Kits | ||
| EKIT-0285 | MLL1 Complex Chemiluminescent Assay Kit | Inquiry |
| EKIT-0286 | MLL1 SAM-Screener Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| HRX | MLH1 | MLL | mll1 |
| MLL2 | MLL3 | MLL4 | MLL5 |
| MLLT1 | MLLT3 | ||
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