| Cat.No.: | EAb-1902 |
| Product Name: | NFκB p50 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This NFkB p50 antibody was raised against a synthetic peptide corresponding to amino acid residues 363-376 of human NFκB p50. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 50 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | PBS containing 0.2% gelatin, 0.01% thimersol and 0.1% sodium azide. |
| Applications: | WB: 1:500 - 1:1,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | NFκB p50 is a member of the NFκB family of transcription factors that are involved in processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. The Rel family includes c-Rel, RelA (NFκB p65, NFκB3) and RelB (I-Rel). Rel proteins form dimers with the NFκB p50 (proteolytically processed from p105/NFκB1) and p52 (proteolytically processed from p100/NFκB2) members of the NFκB family. The NFκB p65/p50 heterodimer is the most abundant form of NFκB.NFκB signaling is negatively regulated by the sequestration of the NFκB complex in the cytoplasm by its association with the IκB family of inhibitory proteins. The IκB Kinase (IKK) complex is the key enzyme involved in the activation and translocation of NFκB. The IKK complex is composed of two catalytic subunits (IKKα and IKKβ) and a regulatory subunit (IKKγ). Upon its activation, the IKK complex phosphorylates IκB proteins (IκBα, IκBα phospho Ser32, 36), which marks them for ubiquitination and degradation. This enables the NFκB complex to translocate to the nucleus where it regulates transcription by binding to DNA. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0182 | NSC 146109 hydrochloride | Inquiry |
| BSM-0404 | Tenovin-3 | Inquiry |
| ◆ Research Kits | ||
| EKIT-0273 | p53 Translocation Assay Kit (Cell-Based) | Inquiry |
| EKIT-0274 | p53 Transcription Factor Activity Assay Kit | Inquiry |
| EKIT-0420 | Human NFkB p50 Transcription Factor Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| p50 | p53 | ||
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