| Cat.No.: | EAb-1896 |
| Product Name: | NFκB p100 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This NFkB p100 antibody was raised against a peptide derived from the C-terminal region of human NFkB p100. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 105 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:500 - 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | NFκB p100 (Nuclear factor NF-kappa-B p100 subunit also known as NFκB2 p100) is a member of the NFkB family of transcription factors that are involved in processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. The family also includes c-Rel, RelA (NFκB p65, NFκB3) and RelB (I-Rel). Rel proteins form dimers with the NFκB p50 (proteolytically processed from p105/NFκB1) and p52 (proteolytically processed from p100/NFκB2) members of the NFκB family that bind DNA and activate transcription. The NFκB p65/p50 heterodimer is the most abundant form of NFκB.NFκB signaling is negatively regulated by the sequestration of the NFκB complex in the cytoplasm by its association with the IκB family of inhibitory proteins. The IκB Kinase (IKK) complex is the key enzyme involved in the activation and translocation of NFκB. The IKK complex is composed of two catalytic subunits (IKKα and IKKβ) and a regulatory subunit (IKKγ). Upon its activation, the IKK complex phosphorylates IκB proteins (IκBα, IκBα phospho Ser32, 36), which marks them for ubiquitination and degradation. This enables the NFκB complex to translocate to the nucleus where it regulates transcription by binding to DNA. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-1896 | NFκB p100 Polyclonal Antibody | Inquiry |
| EAb-3248 | p150 CAF1/CAF Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-2359 | Recombinant Human BRD8/p120 protein | Inquiry |
| PE-2930 | Recombinant Human p150 CAF1/CAF protein | Inquiry |
| PE-3418 | Recombinant NFκB1 p105 protein | Inquiry |
| Related Gene / Proteins | |||
| p100 | p105 | p120 | p150 |
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