| Cat.No.: | EAb-1892 |
| Product Name: | Notch3 Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This Notch3 antibody was raised against a recombinant protein corresponding to the intracytoplasmic portion of human Notch3. |
| Host: | Rat |
| Isotype: | IgG2a |
| Molecular Weight: | 90 and 270 kDa |
| Purification: | Protein G Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 2 µg/ml dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | Notch3 is a member of the Notch family of receptors, which make up a highly conserved cell signaling system. Notch3 functions as a ligand-activated transcription factor that directly transduces extracellular signals in the cell surface into changes in gene expression in the nucleus. Notch3 is membrane bound, serving as an extracellular receptor for the Delta and Serrate family of ligands. Upon activation, the intracellular domain is cleaved and rapidly translocates into the nucleus where it forms a transcriptional complex with the RBP-J DNA binding protein and activates gene expression via recruitment of co-activators of the MAML family. Notch receptors play a critical role in cell fate specification during development and participate in multiple biological processes. Notch signaling is required for undifferentiated embryonic stem cells (ESCs) to participate in the formation of all three embryonic germ layers. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-1892 | Notch3 Monoclonal Antibody | Inquiry |
| EAb-1893 | Notch1 Monoclonal Antibody | Inquiry |
| EAb-1894 | NonO Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-2288 | Recombinant Human NOC2L protein | Inquiry |
| PE-2349 | Recombinant Human C14orf169 / NO66 protein | Inquiry |
| Related Gene / Proteins | |||
| NO66 | NOB1 | NOC2L | NonO |
| NOP58 | Notch1 | Notch3 | |
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