| Cat.No.: | EAb-1891 |
| Product Name: | NR0B1 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This antibody was raised against recombinant human NR0B1 protein. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 60 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 50% glycerol and 0.02% sodium azide. |
| Applications: | WB: 1:500 - 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | NR0B1 (Nuclear Receptor Subfamily 0, Group B, Member 1) is an orphan nuclear receptor and a component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. NR0B1 inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. It may also have a role in embryonic development and in the maintenance of embryonic stem cell pluripotency as it up-regulates Oct-4 expression ES cells. Defects in NR0B1 are a cause of dosage-sensitive sex reversal (DSSR) and X-linked adrenal hypoplasia congenital (XL-AHC). DSSR results from a duplication of the region of the X-chromosome containing NR0B1, resulting in males with two copies of NR0B1, which inhibits normal testis formation, and thus XY individuals develop as females. XL-AHC is a developmental disorder of the adrenal gland, characterized by a structural disorganization of the glands. Hypogonadotropic hypogonadism (HHG) is frequently associated with this disorder. HHG is a condition resulting from or characterized by abnormally decreased gonadal function, with retardation of growth and sexual development. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0076 | Recombinant Human NR2E1 Cell Lysate | Inquiry |
| EL-0130 | Recombinant Human NRIP1 293 Cell Lysate | Inquiry |
| EL-0166 | Recombinant Human NR4A3 293 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0400 | Iberin | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0626 | Recombinant Chicken NR2E1 | Inquiry |
| Related Gene / Proteins | |||
| NR0B1 | NR2C2 | NR2E1 | NR2F2 |
| NR3C1 | NR4A3 | NRF1 | Nrf2 |
| NRIP1 | NRMT1 | NRU | |
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