| Cat.No.: | EAb-1890 |
| Product Name: | NR2C2 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This NR2C2 antibody was raised against a peptide within the N-terminal region of human NR2C2. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 72 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:500 - 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | NR2C2 (nuclear receptor subfamily 2, group C, member 2, TR4, TAK1, TR2R1, hTAK1) is an orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0076 | Recombinant Human NR2E1 Cell Lysate | Inquiry |
| EL-0130 | Recombinant Human NRIP1 293 Cell Lysate | Inquiry |
| EL-0166 | Recombinant Human NR4A3 293 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0400 | Iberin | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0626 | Recombinant Chicken NR2E1 | Inquiry |
| Related Gene / Proteins | |||
| NR0B1 | NR2C2 | NR2E1 | NR2F2 |
| NR3C1 | NR4A3 | NRF1 | Nrf2 |
| NRIP1 | NRMT1 | NRU | |
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