| Cat.No.: | EAb-1847 |
| Product Name: | RAP1 / TERF2IP Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This RAP1 / TERF2IP antibody was raised against a protein corresponding to full-length human RAP1 / TERF2IP. |
| Host: | Mouse |
| Isotype: | IgG2b |
| Molecular Weight: | 60 kDa |
| Purification: | Protein G Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | WB |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | RAP1 / TERF2IP (Repressor/activator protein 1, Telomeric repeat-binding factor 2-interacting protein 1) is a protein associated with telomeres that acts both as a modulator of telomere function and as a regulator of transcription. RAP1 is a component of the shelterin (telosome) protein complex and is involved in the regulation of telomere length and serves to protect telomeric repeats from degradation. In contrast to other components of the shelterin complex, RAP1 is dispensable for telomere end-capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. RAP1 is recruited to telomeric repeats via its interaction with TERF2. Independent of its function in telomeres, RAP1 also acts as a transcriptional regulator. It is recruited to non-telomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. RAP1 is also present in the cytoplasm and associates with the IκB-kinase (IKK) complex and acts as a regulator of the NFκB signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activation of the expression of NFκB target genes. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0044 | RARA Polyclonal Antibody | Inquiry |
| EAb-0176 | TEAD2 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0154 | Recombinant Human TET3 Cell Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0215 | Human TET1 Knockout Cell Line 1bp insertion | Inquiry |
| CL-0217 | Human TET2 Knockout Cell Line 19bp deletion | Inquiry |
| Related Gene / Proteins | |||
| RAC3 | Rad21 | RAD52 | RAD54L2 |
| Rad6 | Rad6B | RAG1 | RAG2 |
| RALY | RALYL | RANBP2 | RAP1 |
| RAR-β | RAR-γ | RARA | TEAD1 |
| TEAD2 | telomerase | TEN1 | TENR More > |
| TERF2IP | TET | TET1 | TET2 |
| TET3 | |||
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