| Cat.No.: | EAb-1811 |
| Product Name: | SREBP-1 Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This SREBP-1 antibody was raised against a recombinant protein corresponding to amino acids 301-407 of human SREBP-1. |
| Host: | Mouse |
| Isotype: | IgG |
| Molecular Weight: | 68 and 125 kDa |
| Purification: | Protein G Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Applications: | IP; EMSA; WB |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | SREBP-1 and SREBP-2 (Sterol regulatory element-binding protein 1 and 2) are members of the basic-helix-loop-helix-leucine zipper (bHLH-ZIP) family of transcription factors and are involved in the regulation of cholesterol homeostasis. SREBP-1 and SREBP-2 are normally membrane bound at the ER and nuclear envelope, but in sterol-depleted cells, the membrane-bound precursors are cleaved to generate a soluble isoforms that translocate to the nucleus. These active forms, which include the bHLH-ZIP domain, activate transcription of genes involved in the uptake and synthesis of cholesterol. |
| Product Types | ||
| ◆ Research Kits | ||
| EKIT-0422 | SREBP-2 Transcription Factor Assay Kit | Inquiry |
| EKIT-0426 | SREBP-1 Transcription Factor Assay Kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0560 | Recombinant Human SRF | Inquiry |
| PE-0561 | Recombinant Human SRF, His-tagged | Inquiry |
| PE-0562 | Recombinant Human SRF, His-tagged | Inquiry |
| Related Gene / Proteins | |||
| SRBD1 | SRC1 | SREBP | SREBP-1 |
| SREBP-2 | SRF | SRP14 | SRP19 |
| SRY | |||
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