| Cat.No.: | EAb-1809 |
| Product Name: | SSRP1 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This antibody was raised against a peptide within the N-terminal region of human SSRP1. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 81 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:500 - 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | SSRP1 (Structure-Specific Recognition Protein 1) is a component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. SSRP1 and Supt16H form a stable heterodimer and this complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. The HMG box DNA-binding domain mediates DNA-binding with both affinity and specificity for DNA damaged globally with cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0067 | Recombinant Human SSRP1 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0574 | Recombinant Human SSRP1, His-tagged | Inquiry |
| PE-0575 | Recombinant Chicken SSRP1 | Inquiry |
| PE-0576 | Recombinant Rat SSRP1 Protein | Inquiry |
| PE-0577 | Recombinant Rhesus monkey SSRP1 Protein, His-tagged | Inquiry |
| Related Gene / Proteins | |||
| SSBP4 | SSRP1 | Ssu72 | |
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