| Cat.No.: | EAb-1806 |
| Product Name: | STAT2 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This antibody was raised against a peptide within the C-terminal region of human STAT2. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 110 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | IP: 10 µl per IP; WB: 1:500 - 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | STAT2 (Signal Transducer And Activator Of Transcription 2, 113kDa) is a signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0164 | Human ST14 Knockout Cell Line | Inquiry |
| CL-0272 | Human STAMBP Knockout Cell Line 1bp insertion | Inquiry |
| CL-0273 | Human STAMBPL1 Knockout Cell Line 2bp deletion | Inquiry |
| CL-0279 | Human STAMBPL1 Knockout Cell Line 2bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0178 | ST18 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| ST14 | ST18 | STAG1 | STAMBP |
| STAMBPL1 | STAT1 | STAT2 | STAT3 |
| STAT4 | STAT5A | STAT5B | STAT6 |
| STAU2 | STYXL1 | ||
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