| Cat.No.: | EAb-1804 |
| Product Name: | STAT3 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This antibody was raised against a peptide within the N-terminal region of human STAT3. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 96 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:1,000 - 1:2,500 ^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | STATs (signal transducers and activators of transcription) are a family of 7 transcription factors that form part of the JAK-STAT signaling cascade. This cascade is the basis of the signal transduction mechanism for many cytokine receptors. Once activated by phosphorylation by JAKs, STATs translocate to the nucleus. Accumulation of STATs in the nucleus is both rapid and tightly controlled. A number of factors regulate the JAK-STAT pathway including STAT dephosphorylation by phosphatases, altered nuclear import-export dynamics of STAT, and STAT gene activation antagonists such as SOCS (suppressors of cytokine signaling) and PIAS (Protein Inhibitors of Activated STATs). |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0164 | Human ST14 Knockout Cell Line | Inquiry |
| CL-0272 | Human STAMBP Knockout Cell Line 1bp insertion | Inquiry |
| CL-0273 | Human STAMBPL1 Knockout Cell Line 2bp deletion | Inquiry |
| CL-0279 | Human STAMBPL1 Knockout Cell Line 2bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0178 | ST18 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| ST14 | ST18 | STAG1 | STAMBP |
| STAMBPL1 | STAT1 | STAT2 | STAT3 |
| STAT4 | STAT5A | STAT5B | STAT6 |
| STAU2 | STYXL1 | ||
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