| Cat.No.: | EAb-1792 |
| Product Name: | TCF7L1 / TCF3 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This TCF7L1 / TCF3 antibody was raised against a peptide from the N-terminus of human TCF7L1 / TCF3. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 80 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | ChIP: 10 µl per ChIP; ChIP-Seq: 10 µl each; WB: 1:500 - 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | TCF3 / TCF7L1 (T-cell factor 3, TCF7L1) is a member of the TCF/LEF family and a component of the Wnt signaling pathway and a dominant downstream effector in embryonic stem cells (ESCs). TCF3 binds to DNA and serves as both a repressor as well as an activator of transcription. TCF3 brings developmental signals directly to the core regulatory circuitry of ES cells to influence the balance between pluripotency and differentiation. TCF3 transcriptionally represses many genes important for maintaining pluripotency and self-renewal, as well as those involved in lineage commitment and stem cell differentiation. This effect is in part mediated by the corepressors transducin-like enhancer of split 2 (TLE2) and C-terminal Binding Protein (CtBP). |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0079 | Recombinant Human TCF21 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0664 | Recombinant Chicken TCF21 | Inquiry |
| PE-0665 | Recombinant Zebrafish TCF21 | Inquiry |
| PE-0666 | Recombinant Mouse TCF21 Protein | Inquiry |
| PE-0667 | Recombinant Rhesus monkey TCF21 Protein, His-tagged | Inquiry |
| Related Gene / Proteins | |||
| TCF3 | TCF21 | TCF4 | TCF7 |
| TCF7L1 | |||
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