| Cat.No.: | EAb-1778 |
| Product Name: | Bcl6 Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This Bcl6 antibody was raised against a full-length protein corresponding to human Bcl6. |
| Host: | Mouse |
| Isotype: | IgG1 |
| Molecular Weight: | 80 kDa |
| Purification: | Protein G Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | IHC (FFPE), WB |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | Bcl6 (B-cell lymphoma 6 protein, Bcl5, LAZ3, ZBTB27, ZNF51) is sequence-specific transcriptional repressor that is required for the formation of lymph node germinal centers (GC). Bcl6 is a member of the BTB-POZ family of transcriptional regulators and contains six Kruppel-type zinc fingers. The POZ domain in the amino terminus of Bcl6 is involved in the recruitment of corepressor proteins including NCoR, BCoR, SMRT, Mi-2/NURD and several HDACs. Bcl6 promotes proliferative expansion of B-cells in the germinal center through repression of genes regulating cell cycle and differentiation. Bcl6 also suppresses the DNA damage response, to prevent class-switch recombination being repaired. Unregulated expression of Bcl6 is involved in the development of many B-cell lymphomas. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0087 | Recombinant Human BCOR 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0708 | Recombinant Human BCOR, GST-tagged | Inquiry |
| PE-0709 | Recombinant Zebrafish BCOR | Inquiry |
| PE-0710 | Recombinant Mouse BCOR Protein | Inquiry |
| PE-0711 | Recombinant Human BCOR Protein, GST-tagged | Inquiry |
| Related Gene / Proteins | |||
| Bcl10 | BCL11A | Bcl3 | Bcl6 |
| BCOR | |||
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