| Cat.No.: | EAb-1521 |
| Product Name: | USP30 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Conjugate: | Unconjugated |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Protein G Purified |
| Appearance: | Liquid |
| Formulation: | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4. |
| Applications: | ELISA, IHC, WB |
| Recommended Dilutions/Conditions: |
ELISA, WB, IHC; Recommended dilution: WB:1:500-2000, IHC:1:20-1:200 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | Ubiquitin carboxyl-terminal hydrolase 30 (EC:3.4.19.121 Publication, USP30, Deubiquitinating enzyme 30, Ubiquitin thioesterase 30, Ubiquitin-specific-processing protease 30, Ub-specific protease 30 |
| Scientific Background: | Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0006 | USP3 Polyclonal Antibody | Inquiry |
| EAb-0007 | USP25 Polyclonal Antibody | Inquiry |
| EAb-0008 | USP2 Polyclonal Antibody | Inquiry |
| EAb-0009 | USP1 Polyclonal Antibody | Inquiry |
| EAb-0010 | USP7 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| USF1 | USP1 | USP10 | USP11 |
| USP12 | USP13 | USP14 | USP15 |
| USP16 | USP17L11 | USP17L12 | USP17L13 |
| USP17L15 | USP17L17 | USP17L1P | USP17L2 |
| USP17L22 | USP17L28 | USP17L3 | USP17L5 More > |
| USP17L8 | USP18 | USP19 | USP2 |
| USP20 | USP21 | USP22 | USP24 |
| USP25 | USP26 | USP27X | USP28 |
| USP29 | USP3 | USP30 | USP31 |
| USP32 | USP33 | USP34 | USP35 |
| USP36 | USP37 | USP38 | USP40 |
| USP42 | USP43 | USP44 | USP45 |
| USP46 | USP47 | USP48 | USP49 |
| USP5 | USP53 | USP54 | USP6 |
| USP6NL | USP7 | USP8 | USP9X |
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