| Cat.No.: | EAb-1426 |
| Product Name: | COPS7B Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Conjugate: | Unconjugated |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Protein G Purified |
| Appearance: | Liquid |
| Formulation: | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4. |
| Applications: | ELISA, IF, IHC, WB |
| Recommended Dilutions/Conditions: |
ELISA, WB, IHC, IF; Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | COP9 signalosome complex subunit 7b, SGN7b, Signalosome subunit 7b, JAB1-containing signalosome subunit 7b, COPS7B, CSN7B |
| Scientific Background: | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0033 | Human COMMD3-BMI1 Knockout Cell Line | Inquiry |
| CL-0262 | Human COPS6 Knockout Cell Line 40bp deletion | Inquiry |
| CL-0271 | Human COPS7A Knockout Cell Line 2bp deletion | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0212 | Recombinant Human C17orf79 293 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0278 | Entacapone | Inquiry |
| Related Gene / Proteins | |||
| COMMD2 | COMMD3 | COMMD4 | COMMD6 |
| COMMD9 | COMT | COP1 | COPRS |
| COPS6 | COPS7A | COPS7B | CoREST |
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