| Cat.No.: | EAb-0923 |
| Product Name: | SMYD2 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Conjugate: | Unconjugated |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Applications: | WB |
| Recommended Dilutions/Conditions: |
WB; Recommended dilution: WB 1:500 - 1:2000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | KMT3C, HSKM-B, ZMYND14 |
| Scientific Background: | SMYD2 (SET and MYND Domain Containing 2) is a member of the SMYD family of protein methyltransferases. All family members (SMYD1, SMYD2, SMYD3, SMYD4, and SMYD5) contain a conserved catalytic SET domain, first identified in Drosophila Su[var]3-9, Enhancer of zeste, and Trithorax proteins. Split by the MYN domain/zinc finger motif, this domain is believed to facilitate protein-protein interactions. SMYD2 localizes to cytoplasm and the nucleus and is also highly expressed in mouse heart, brain, liver, kidney, thymus, and ovary, as well as in the developing embryo of the mouse. SMYD2 is able to repress transcription by interacting with the Sin3A repressor complex and methylating lys36 of histone H3. SMYD2 also interacts with HSP90alpha and methylates lys4 of histone H3. Additionally, SMYD2 can methylate p53 at lys370 to repress p53-mediated transcriptional activation and apoptosis. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0019 | SMARCA4 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0063 | Recombinant Human SMARCC2 293 Cell Lysate | Inquiry |
| EL-0064 | Recombinant Human SMARCB1 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0080 | AZ-505 ditrifluoroacetate | Inquiry |
| ◆ Research Kits | ||
| EKIT-0120 | BRG1 bromodomain TR-FRET Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| SMAD3 | SMAD4 | SMARCA1 | SMARCA2 |
| SMARCA4 | SMARCA5 | SMARCA6 | SMARCAD1 |
| SMARCAL1 | SMARCB1 | SMARCC1 | SMARCC2 |
| SMARCD1 | SMARCD2 | SMARCD3 | SMARCE1 |
| SMC1-α | SMC3 | SMC4 | SMCHD1 More > |
| SMCX | SMN | SMN1 | SMN2 |
| SMOC2 | SMRT | SMT3 | SMUG1 |
| SMURF2 | SMYD1 | SMYD2 | SMYD2B |
| SMYD3 | SMYD4 | SMYD5 | |
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