SET1 Polyclonal Antibody


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Cat.No.:  EAb-0908
Product Name:  SET1 Polyclonal Antibody
Antibody Type:  Polyclonal
Conjugate:  Unconjugated
Host:  Rabbit
Isotype:  IgG
Purification:  Protein G Purified
Appearance:  Liquid
Formulation:  0.03% Proclin 300. 50% Glycerol, 0.01M PBS, pH 7.4.
Applications:  ELISA, IHC
Species Reactivity:  Human
Storage:  -20°C
Warning:  For Research Use Only! Not For Use in Humans.
Alternative Name:  Histone-lysine N-methyltransferase SETD1A antibody, hSET1A antibody, KMT2F antibody, Lysine N methyltransferase 2F antibody, SET domain containing protein 1A antibody, Set1 Ash2 histone methyltransferase complex subunit SET1 antibody, SET1A antibody, SETD1A antibody
Scientific Background:  The Set1/COMPASS histone methyltransferase complex contains the SET1 histone methyltransferase protein. It functions as a transcriptional co-activator and methylates histone H3 at Lys4 (H3K4). Although first identified in yeast, SET1-related proteins are also found within mammals, including proteins SET1A, SET1B, MLL1, MLL2, MLL3, and MLL4. These proteins work together in a complex to methylate histone H3 at Lys4. In addition, SET1/COMPASS histone methyltransferase complexes are thought to play a role in leukemogenesis due to a significant amount of hematological malignancies containing MLL translocations.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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