| Cat.No.: | EAb-0622 |
| Product Name: | p53 K292 Ac Polyclonal Antibody |
| Product Overview: | Anti-p53 (ac Lys292) (RABBIT) Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Prepared from whole rabbit serum produced by repeated immunizations with a synthetic acetylated peptide surrounding Lysine 292 of human p53. |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | affinity purified from monospecific antiserum by immunoaffinity chromatography. |
| Appearance: | Liquid |
| Formulation: | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
| Applications: | ELISA and western blotting |
| Recommended Dilutions/Conditions: |
ELISA: User Optimized; Western Blot: 1:1000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Cross Reactivity: | human |
| Shipping: | Dry Ice |
| Storage: | -20°C |
| Storage Buffer: | 0.01% (w/v) Sodium Azide |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | UniProtKB - P04637; NCBI - NP_000537.3; GeneID - 7157 |
| Alternative Name: | rabbit anti-p53 Ac-Lys292 antibody, rabbit anti-p53 K292ac antibody, cellular tumor antigen p53, tumor suppressor p53, phosphoprotein p53, Antigen NY-CO-13, TP53 |
| Scientific Background: | TP53 (tumor suppressor gene p53) is one of the most well-studied genes that suppresses tumor formation and renders protection against DNA damage by inducing cell cycle arrest, DNA repair, or apoptosis. TP53 signaling is triggered through numerous cellular events ranging from DNA damage to hypoxia, stress and a plethora of other causes. Upon activation, p53 acts as zinc-containing transcriptional regulator and initiates a cascade of events that determines the cellular outcome including cell cycle arrest, apoptosis, senescence, DNA repair, development, differentiation and tissue homeostasis. Cell cycle arrest is induced by p53 via trans-activating genes such as p21 (CDK-inhibitor 1, cyclin dependent kinase) and others. Interestingly, p53 itself is capable of triggering cellular responses (survival or induced cell death) as well. Mutations or deletions in the TP53 gene are present in nearly 50% of human cancers, and primarily results in impaired tumor suppressor function. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0182 | NSC 146109 hydrochloride | Inquiry |
| BSM-0404 | Tenovin-3 | Inquiry |
| ◆ Research Kits | ||
| EKIT-0273 | p53 Translocation Assay Kit (Cell-Based) | Inquiry |
| EKIT-0274 | p53 Transcription Factor Activity Assay Kit | Inquiry |
| EKIT-0420 | Human NFkB p50 Transcription Factor Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| p50 | p53 | ||
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