| Cat.No.: | EAb-0491 |
| Product Name: | Dnmt2 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This antibody was raised against synthetic peptides corresponding amino acids 39-53 and 361-376 of mouse Dnmt2. |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | TRDMT1 |
| Purification: | Protein G purified |
| Appearance: | Liquid |
| Formulation: | PBS containing 0.05% BSA |
| Applications: | WB |
| Recommended Dilutions/Conditions: |
Western Blot 2 ug/ml Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Storage Buffer: | 0.05% Sodium Azide |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | DMNT2; DNA (cytosine-5-)-methyltransferase 2; DNA (cytosine-5)-methyltransferase-like protein 2; DNA methyltransferase homolog HsaIIP; DNA methyltransferase-2; DNA MTase homolog HsaIIP; DNMT2; EC 2.1.1; EC 2.1.1.29; M.HsaIIP; MHSAIIP; PUMET; RNMT1; tRNA (cytosine-5-)-methyltransferase; tRNA aspartic acid methyltransferase 1 |
| Scientific Background: | Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. Dnmt2 contains all the sequence motifs diagnostic of DNA (cytosine-5)-methyltransferases but appears to lack the large N-terminal regulatory domain common to other eukaryotic methyltransferases. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0008 | Vinorelbine Tartrate | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0027 | Recombinant Human DNMT3A 293 Cell Lysate | Inquiry |
| EL-0028 | Recombinant Human DNMT3B 293 Cell Lysate | Inquiry |
| EL-0029 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| EL-0030 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| DNA alkyltransferase | DNAJC2 | DNAS1L1 | DNASE1L3 |
| DNMT | DNMT1 | DNMT2 | DNMT3A |
| DNMT3B | DNMT3L | DNMT4 | |
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