| Cat.No.: | EAb-0333 |
| Product Name: | HMGB1 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Synthesized peptide derived from the Internal region of human HMG-1 |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Affinity purification |
| Appearance: | Liquid |
| Applications: | WB, IHC-p, IF, ELISA |
| Recommended Dilutions/Conditions: |
WB: 1:500-1:2000; IHC: 1:100-1:300; IF: 1:200-1:1000; ELISA: 1:20000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse, Rat |
| Storage: | -20°C |
| Storage Buffer: | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | P09429 |
| Alternative Name: | Amphoterin,Chromosomal protein,nonhistone,HMG1,DKFZp686A04236,High mobility group 1,High mobility group box 1,High mobility group protein 1,High mobility group protein B1,high-mobility group (nonhistone chromosomal) protein 1,HMG-1,HMG1,HMG3,HMGB 1,HMGB1,HMGB1,NONHISTONE CHROMOSOMAL PROTEIN HMG1,SBP 1,Sulfoglucuronyl carbohydrate binding protein |
| Scientific Background: | High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2,members of the NFκB family, ATF-2 and c-Jun to activate transcription.Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0084 | HMG2L1 Polyclonal Antibody | Inquiry |
| EAb-0293 | HMGB4 Polyclonal Antibody | Inquiry |
| EAb-0309 | HMGB3 Polyclonal Antibody | Inquiry |
| EAb-0329 | HMGB1 Polyclonal Antibody | Inquiry |
| EAb-0333 | HMGB1 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| HMG-1 | HMG2L1 | HMG4 | HMGA1 |
| HMGA2 | HMGB1 | HMGB2 | HMGB3 |
| HMGB4 | HMGN1 | HMGN2 | HMGN3 |
| HMGN5 | HMT1 | ||
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