| Cat.No.: | EAb-0261 |
| Product Name: | PAD4 Monoclonal Antibody (Clone 6D8) |
| Antibody Type: | Monoclonal |
| Clone Designation: | 6D8 |
| Immunogen: | Full length recombinant PAD4 protein |
| Host: | Mouse |
| Isotype: | IgG1 |
| Appearance: | Liquid |
| Formulation: | 100 µg of protein G-purified IgG |
| Applications: | ELISA, WB |
| Species Reactivity: | Human |
| Shipping: | Wet ice |
| Storage: | -20°C |
| Storage Buffer: | PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q9UM07 |
| Alternative Name: | HL-60 PAD;PADI4;Peptidylarginine Deiminase IV;Protein-arginine Deiminase Type-4 |
| Scientific Background: | Protein arginine deiminases (PADs) are guanidino-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4 and PAD6. All enzymes are cytosolic except for PAD4 which is localized in the nucleus. PAD4 is a homodimer that functions as a transcriptional coregulator to catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. PAD4 substrates include histones H2A, H3, and H4, whose post-translational modifications play a large role in gene regulation. Benzoylated arginine substrates like N-α-benzoyl-L-arginine ethyl ester have proven to be useful tools for characterization of PAD4, having similar kinetic properties to the natural substrates. PAD4 itself can undergo autocitrullination at several sites, which inhibits its enzymatic activity and may play an important role in regulating citrullination in cells. PAD4 activity is increased in rheumatoid arthritis, producing an abundance of citrulline-containing proteins that can be recognized by autoantibodies, causing the immune system to attack its own tissues. PAD4 has also been implicated in several other diseases including multiple sclerosis, Alzheimer’s, glaucoma, and cancer. The predicted size of PAD4 is 74.1 kDa and PAD4 Monoclonal Antibody (Clone 6D8) detects a band at 74 kDa by western blot. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0059 | PARP Monoclonal Antibody | Inquiry |
| EAb-0061 | PARP Polyclonal Antibody | Inquiry |
| EAb-0062 | PARP (Cleaved) Polyclonal Antibody | Inquiry |
| EAb-0063 | PARP (Cleaved) Polyclonal Antibody | Inquiry |
| EAb-0064 | Paf1 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| PABPC1L2A | PABPC5 | PABPN1 | PAD |
| PAD1 | PAD2 | PAD3 | PAD4 |
| PADI1 | PADI2 | PADI3 | PADI4 |
| PADI6 | PAF1 | PAN2 | PAPD1 |
| PAPD4 | PAPD5 | PAPD7 | PAPOLA More > |
| PAPOLB | PARD6A | PARG | PARK2 |
| PARK7 | PARP | PARP1 | PARP10 |
| PARP11 | PARP12 | PARP14 | PARP15 |
| PARP16 | PARP2 | PARP3 | PARP4 |
| PARP6 | PARP7 | PARP8 | PARP9 |
| PAX5 | PAX6 | PAX7 | PAX9 |
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