| Cat.No.: | EAb-0253 |
| Product Name: | Histone H3 K36M Monoclonal Antibody (Clone RM193) |
| Description: | This antibody reacts to the H3K36M mutant and does not detect wild-type histone H3. |
| Antibody Type: | Monoclonal |
| Clone Designation: | RM193 |
| Immunogen: | A peptide corresponding to histone H3 K36M mutant |
| Host: | Rabbit |
| Isotype: | IgG |
| Appearance: | Liquid |
| Formulation: | 50 µg of protein A affinity purified-antibody from an animal origin-free culture supernatant |
| Applications: | ELISA, ICC/IF, IHC, and WB |
| Species Reactivity: | All species |
| Shipping: | Wet ice |
| Storage: | -20°C |
| Storage Buffer: | 50% glycerol/PBS containing 1% BSA and 0.09% sodium azide |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | Histone H3 undergoes many modifications including acetylation, methylation, and phosphorylation that are important for regulation of gene transcription. Lysine 36 of histone 3 (H3K36) has functionally relevant acetylation and methylation states with roles in transcriptional activation. More than 90% of chondroblastomas contain a heterozygous mutation, replacing H3K36 with methionine 36 (H3K36M) in the histone H3 variant H3.3. |
| Product Types | ||
| ◆ Research Kits | ||
| EKIT-0001 | Acetyl Histone H3-K14 Quantification Kit (Colorimetric) | Inquiry |
| EKIT-0002 | Acetyl Histone H3-K14 Quantification Kit (Fluorometric) | Inquiry |
| EKIT-0003 | Acetyl Histone H3-K18 Quantification Kit (Colorimetric) | Inquiry |
| EKIT-0004 | Acetyl Histone H3-K18 Quantification Kit (Fluorometric) | Inquiry |
| EKIT-0005 | Acetyl Histone H3-K23 Quantification Kit (Colorimetric) | Inquiry |
| Related Gene / Proteins | |||
| H3K10 | H3K115 | H3K122 | H3K123 |
| H3K14 | H3K18 | H3K23 | H3K27 |
| H3K36 | H3K37 | H3K4 | H3K5 |
| H3K56 | H3K64 | H3K79 | H3K80 |
| H3K9 | H3R128 | H3R17 | H3R2 More > |
| H3R26 | H3R8 | H3R9 | H3S10 |
| H3S28 | H3S31 | H3S32 | H3T11 |
| H3T118 | H3T3 | H3T32 | H3T41 |
| H3T45 | H3T6 | H3T80 | H3Y41 |
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