| Cat.No.: | EAb-0238 |
| Product Name: | Dnmt3a (mouse) Monoclonal Antibody (64B1446) |
| Antibody Type: | Monoclonal |
| Immunogen: | Recombinant mouse Dnmt3a (DNA methyltransferase-3a). |
| Host: | Mouse |
| Isotype: | IgG1 |
| Specificity: | Recognizes C-terminal epitope aa 705-908 of mouse Dnmt3a. |
| Purification: | Protein G-affinity purified. |
| Appearance: | Liquid |
| Formulation: | Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide. |
| Applications: | ICC, IHC, IP, WB, ChIP |
| Recommended Dilutions/Conditions: |
Immunocytochemistry (5µg/ml)Immunohistochemistry (1:400)Western Blot (2µg/ml). Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Mouse |
| Cross Reactivity: | Weakly cross-reacts with human Dnmt3a. |
| Shipping: | Blue Ice |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | O88508 |
| Alternative Name: | DNMT3a |
| Scientific Background: | Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, three families of mammalian DNA methyltransferase genes have been identified which include DNMT1, DNMT2, and DNMT3. DNMT1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. DNMT2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The DNMT3 family members, DNMT3a and DNMT3b, are strongly expressed in ES cells but their expression is down regulated in differentiating embyonic stem (ES) cells and is low in adult somatic tissue. It has been shown that naturally occurring mutations of DNMT3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0008 | Vinorelbine Tartrate | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0027 | Recombinant Human DNMT3A 293 Cell Lysate | Inquiry |
| EL-0028 | Recombinant Human DNMT3B 293 Cell Lysate | Inquiry |
| EL-0029 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| EL-0030 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| DNA alkyltransferase | DNAJC2 | DNAS1L1 | DNASE1L3 |
| DNMT | DNMT1 | DNMT2 | DNMT3A |
| DNMT3B | DNMT3L | DNMT4 | |
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