| Cat.No.: | EAb-0237 |
| Product Name: | Dnmt1 Monoclonal Antibody (60B1220.1) |
| Antibody Type: | Monoclonal |
| Immunogen: | Synthetic peptide corresponding to aa 637-650 of human Dnmt1 (DNA methyltransferase-1). |
| Host: | Mouse |
| Isotype: | IgG1κ |
| Antibody Target: | DNMT1 |
| Purification: | Protein G-affinity purified. |
| Appearance: | Liquid |
| Formulation: | In PBS containing 0.05% BSA and 0.05% sodium azide. |
| Applications: | ICC, IHC (PS), IP, WB, ChIP |
| Recommended Dilutions/Conditions: |
Immunohistochemistry (paraffin sections, 1-2µg/ml)Western Blot (0.1-0.5µg/ml). Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse, Zebrafish |
| Shipping: | Blue Ice |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | P26358 |
| Alternative Name: | DNA methyltransferase-1 |
| Scientific Background: | Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting, and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, three families of mammalian DNA methyltransferase genes have been identified which include DNMT1, DNMT2, and DNMT3. DNMT1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. DNMT1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. DNMT1 also cooperates with Rb to repress transcription from promoters containing E2F-binding sites sμggesting a link between DNA methylation, histone deacetylase, and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0008 | Vinorelbine Tartrate | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0027 | Recombinant Human DNMT3A 293 Cell Lysate | Inquiry |
| EL-0028 | Recombinant Human DNMT3B 293 Cell Lysate | Inquiry |
| EL-0029 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| EL-0030 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| DNA alkyltransferase | DNAJC2 | DNAS1L1 | DNASE1L3 |
| DNMT | DNMT1 | DNMT2 | DNMT3A |
| DNMT3B | DNMT3L | DNMT4 | |
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