| Cat.No.: | EAb-0176 |
| Product Name: | TEAD2 Polyclonal Antibody |
| Product Overview: | Polyclonal antibody to detect endogenous levels of TEAD2 in human and mouse. |
| Antibody Type: | Polyclonal |
| Immunogen: | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TEAD2 |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | TEAD2 |
| Purification: | Affinity purified |
| Appearance: | Colorless liquid |
| Formulation: | In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide |
| Applications: | WB, IH, IF/IC |
| Recommended Dilutions/Conditions: |
WB; 1:500 – 1:2000, IHC; 1:50 – 1:200, IF/IC; 1:50 – 1:100, ChIP 1:100 – 1:500 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Positive Control: | WB: HEK293, RAW264.7, H9C2 cell lysate; IHC: human bresat cancer tissue; IF: HepG2 cells |
| Species Reactivity: | Human, Mouse |
| Shipping: | Gel Pack |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q15562 |
| Alternative Name: | TEF4, Transcriptional enhancer factor TEF-4, TEA domain family member 2, TEAD-2 |
| Scientific Background: | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0154 | Recombinant Human TET3 Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0176 | TEAD2 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0215 | Human TET1 Knockout Cell Line 1bp insertion | Inquiry |
| CL-0217 | Human TET2 Knockout Cell Line 19bp deletion | Inquiry |
| CL-0218 | Human TET3 Knockout Cell Line 14bp deletion | Inquiry |
| Related Gene / Proteins | |||
| TEAD1 | TEAD2 | telomerase | TEN1 |
| TENR | TERF2IP | TET | TET1 |
| TET2 | TET3 | ||
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