| Cat.No.: | EAb-0082 |
| Product Name: | HP1α, β and γ Polyclonal Antibody |
| Product Overview: | Polyclonal Antibody to detect HP1α, β and γ in human and mouse samples. |
| Antibody Type: | Polyclonal |
| Immunogen: | Polyclonal antibody raised in rabbit against human HP1 β (Heterochromatin protein 1 homolog beta), using the full length recombinant GST tagged protein. The antibody also recognizes the α and γ isoforms. |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | HP1α, β and γ |
| Purification: | Protein G purified |
| Appearance: | Colorless liquid |
| Formulation: | In PBS with 0.05% sodium azide and 0.05% ProClin 300. |
| Applications: | Western blot, IF, ChIP. |
| Recommended Dilutions/Conditions: |
Western Blot: 1:1000, IF: 1:500, ChIP: 4 µg/ChIP Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Positive Control: | ChIP: NIH 3T3 cells, Western blot: HeLa cells, IF: HeLa cells. |
| Species Reactivity: | Human, mouse |
| Shipping: | Gel Pack |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | P45973, P83916, Q13185 |
| Alternative Name: | CBX5, 1, 3 |
| Scientific Background: | HP1 alpha, beta and gamma are components of heterochromatin. They recognize and bind histone H3 tails methylated at ‘Lys-9’, leading to epigenetic repression of transcription. HP1 alpha, beta and gamma also interact with lamin B receptor (LBR), thereby contributing to the association of heterochromatin with the inner nuclear membrane. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0051 | Human CBX1 Knockout Cell Line 32bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0082 | HP1α, β and γ Polyclonal Antibody | Inquiry |
| EAb-0083 | HP1α Polyclonal Antibody | Inquiry |
| EAb-0149 | CBX1 Polyclonal Antibody | Inquiry |
| EAb-0677 | CBX1 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| HP1 | HP1BP3 | ||
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