| Cat.No.: | EAb-0080 |
| Product Name: | JARID1C Polyclonal Antibody |
| Product Overview: | Polyclonal Antibody to detect Jarid 1c in human and mouse samples. |
| Antibody Type: | Polyclonal |
| Immunogen: | Polyclonal antibody raised in rabbit against mouse Jarid1c (jumonji, AT rich interactive domain 1C), using 3 KLH-conjugated synthetic peptides containing sequences from the inner part of the protein. |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | Jarid1c |
| Purification: | Whole Anti-Sera |
| Appearance: | Colorless liquid |
| Formulation: | In PBS with 0.05% (W/V) sodium azide. |
| Applications: | Western blot, ELISA. |
| Recommended Dilutions/Conditions: |
Western Blot: 1:1000, ELISA: 1:500. Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Positive Control: | Western blot: HeLa cells, ELISA: Peptides. |
| Species Reactivity: | Human, mouse |
| Shipping: | Gel Pack |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | P41229 |
| Alternative Name: | KDM5C, MRXJ, MRXSJ, SMCX, XE169 |
| Scientific Background: | Jarid1c is a histone demethylase which specifically demethylates lysine 4 of histone H3, thereby playing a central role in the regulation of transcription and chromatin remodelling. Jarid1c demethylates the trimethylated and dimethylated lysine 4, but not the monomethylated form. Further, Jarid1c participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Mutations in the Jarid1c gene have been associated with X-linked mental retardation. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0002 | AT9283 | Inquiry |
| ◆ Cell Lines | ||
| CL-0017 | Human JARID2 Knockout Cell Line 11bp deletion | Inquiry |
| CL-0081 | Human JARID2 Knockout Cell Line 11bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0079 | JARID2 Polyclonal Antibody | Inquiry |
| EAb-0080 | JARID1C Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JADE1 | JAK | JAK1 | JAK2 |
| JAK3 | JAKMIP1 | JARID | JARID1 |
| JARID1A | JARID1B | JARID1C | JARID2 |
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