| Cat.No.: | EAb-0069 |
| Product Name: | MBD1 Polyclonal Antibody |
| Product Overview: | Polyclonal Antibody to detect MBD1 in human samples. |
| Antibody Type: | Polyclonal |
| Immunogen: | MBD1 (Methyl-CpG-binding domain protein 1) synthetic peptide containing a sequence from the N-terminal conjugated to KLH |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | MBD1 |
| Purification: | Affinity Purified |
| Appearance: | Colorless liquid |
| Formulation: | In PBS with 0.05% sodium azide and 0.05% ProClin 300. |
| Applications: | Western blot, ELISA, ChIP. |
| Recommended Dilutions/Conditions: |
ChIP: 1.5 µg/ChIP, WB: 1:500, ELISA: 1:1000. Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Positive Control: | Western blot: Hela cells, ELISA: peptides, ChIP: U2OS cells. |
| Species Reactivity: | Human |
| Shipping: | Gel Pack |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q9UIS9 |
| Alternative Name: | CXXC3, PCM1, RFT, Methyl-CpG-Binding Domain 1 |
| Scientific Background: | MBD1 is a transcriptional repressor that specifically binds to methylated CpG dinucleotides in promoter sequences. MBD1 acts by recruiting a variety of histone deacetylases (HDAC’s) and chromatin remodelling factors. MBD1-dependent transcriptional repression is mediated by ATF7IP through the recruitment of factors such as the histone methyltransferase SETDB1. MBD1 probably forms a complex with SETDB1 and ATF7IP which couples DNA methylation to H3K9 trimethylation and represses transcription. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0001 | Recombinant Human MBD1 Cell Lysate | Inquiry |
| EL-0002 | Recombinant Human MBD3 Cell Lysate | Inquiry |
| EL-0003 | Recombinant Human MBD3L1 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0001 | Recombinant Chicken MBD2 | Inquiry |
| PE-0002 | Recombinant Zebrafish MBD2 | Inquiry |
| Related Gene / Proteins | |||
| MBD1 | mbd2 | MBD3 | MBD3L1 |
| MBD3L2 | MBD3L3 | MBD3L4 | MBD3L5 |
| MBD4 | MBD5 | MBD6 | MBIP |
| MBTD1 | |||
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