| Cat.No.: | EAb-0067 |
| Product Name: | MeCP2 Polyclonal Antibody |
| Product Overview: | Polyclonal Antibody to detect MeCP2 in human samples. |
| Antibody Type: | Polyclonal |
| Immunogen: | MeCP2 (Methyl-CpG-binding domain protein 2) synthetic peptide containing a sequence from the C-terminal conjugated to KLH |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | MeCP2 |
| Purification: | Affinity Purified |
| Appearance: | Colorless liquid |
| Formulation: | In PBS with 0.05% sodium azide and 0.05% ProClin 300. |
| Applications: | Western blot, ELISA, ChIP. |
| Recommended Dilutions/Conditions: |
ChIP: 5 µg/ChIP, WB: 1:1000, ELISA: 1:1000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Positive Control: | Western blot: Hela cells, ELISA: peptides, ChIP: U2OS cells. |
| Species Reactivity: | Human |
| Shipping: | Gel Pack |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | P51608 |
| Alternative Name: | AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RTS, RTT |
| Scientific Background: | MeCP2 is a chromosomal protein with abundant binding sites in the chromatin. It belongs to the family of methyl CpG binding proteins which also comprises MBD1, MBD2, MBD3 and MBD4. MeCP2 can bind specifically to methylated promoters, thereby repressing transcription. This transcriptional repression is mediated through interaction with histone deacetylase and the corepressor SIN3A. MeCP2 also is essential for development. Mutations in MeCP2 are the cause of several types of mental retardation including Rett syndrome, a progressive neurological disorder that causes mental retardation in females and mental retardation syndromic X-linked type 13, and may also be involved in Angelman syndrome and susceptibility to some types of autism. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0043 | Recombinant Human MECP2 293 Cell Lysate | Inquiry |
| EL-0111 | Recombinant Human MEF2B Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0067 | MeCP2 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0109 | Human MECP2 Knockout Cell Line 1bp insertion | Inquiry |
| CL-0110 | Human MEN1 Knockout Cell Line 1bp insertion | Inquiry |
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