| Cat.No.: | EAb-0019 |
| Product Name: | SMARCA4 Polyclonal Antibody |
| Product Overview: | Polyclonal antibody to detect SMARCA4 in human, mouse and rat samples. |
| Antibody Type: | Polyclonal |
| Immunogen: | A synthetic peptide of human SMARCA4 |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | SMARCA4 |
| Purification: | Affinity purified |
| Appearance: | Colorless liquid |
| Formulation: | 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3 |
| Applications: | Western blot, Immunohistochemistry |
| Recommended Dilutions/Conditions: |
Western blot: 1:500 – 1:2000, IHC: 1:50 – 1:200. Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Positive Control: | Western Blot: Various cell lysates |
| Species Reactivity: | Human, mouse, rat |
| Shipping: | Gel Pack |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | P51532 |
| Alternative Name: | BAF190, BRG1, FLJ39786, SNF2, SNF2BETA, SNF2L4, SNF2LB, SWI2, hSNF2b. |
| Scientific Background: | The modulation of chromatin structure is an essential component in the regulation of transcriptional activation and repression. Modifications can be made by at least two evolutionarily conserved strategies, through the disruption of histoneDNA contacts by ATPdependent chromatin remodelers, or by histone tail modifications including methylation and acetylation. One of the four classes of ATPdependent histone remodelers is the SWI/SNF complex, the central catalytic subunit of which is Brg1 or the highly related protein hBRM. This SWI/SNF complex contains varying subunits but its association with either Brg1 or hBRM remains constant. SWI/SNF complexes have been shown to regulate gene activation, cell growth, the cell cycle and differentiation. Brg1/hBRM has been shown to regulate transcription through enhancing transcriptional activation of glucocorticoid receptors. Although usually associated with transcriptional activation, Brg1/hBRM have also been found in complexes associated with transcriptional repression including with HDACs, Rb and Tif1β. Brg1/hBRM plays a vital role in the regulation of gene transcription during early mammalian embryogenesis. In addition, Brg1/hBRM also plays a role as a tumor suppressors and Brg1 is mutated in several tumor cell lines. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0019 | SMARCA4 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0063 | Recombinant Human SMARCC2 293 Cell Lysate | Inquiry |
| EL-0064 | Recombinant Human SMARCB1 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0080 | AZ-505 ditrifluoroacetate | Inquiry |
| ◆ Research Kits | ||
| EKIT-0120 | BRG1 bromodomain TR-FRET Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| SMAD3 | SMAD4 | SMARCA1 | SMARCA2 |
| SMARCA4 | SMARCA5 | SMARCA6 | SMARCAD1 |
| SMARCAL1 | SMARCB1 | SMARCC1 | SMARCC2 |
| SMARCD1 | SMARCD2 | SMARCD3 | SMARCE1 |
| SMC1-α | SMC3 | SMC4 | SMCHD1 More > |
| SMCX | SMN | SMN1 | SMN2 |
| SMOC2 | SMRT | SMT3 | SMUG1 |
| SMURF2 | SMYD1 | SMYD2 | SMYD2B |
| SMYD3 | SMYD4 | SMYD5 | |
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