| Cat.No.: | EAb-0015 |
| Product Name: | TIP60 Polyclonal Antibody |
| Product Overview: | Polyclonal antibody to detect TIP60 (a HAT) in Human, Chimpanzee, Orangutan, Equine, Canine, Mouse, Bovine, Rat, Opossum, Zebrafish and Xenopus samples |
| Antibody Type: | Polyclonal |
| Immunogen: | Synthetic peptide within the region of human TIP60 amino acids 480-530. |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | TIP60 |
| Purification: | Protein A purified |
| Appearance: | Colorless liquid |
| Formulation: | 50 µg of antibody in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide. |
| Applications: | Western blot, Immunohistochemistry |
| Recommended Dilutions/Conditions: |
Western blot: 0.25-1.0 µg/ml, IHC (paraffin embedded sections): 5 µg/ml. Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Positive Control: | Western blot: Human brain lysate, mouse brain lysate, rat brain lysate |
| Species Reactivity: | Human, chimpanzee, orangutan, equine, canine, mouse, bovine, rat, opossum, zebrafish, xenopus |
| Shipping: | Gel Pack |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q92993 |
| Alternative Name: | Lysine Acetyltransferase 5; KAT5 |
| Scientific Background: | TIP60, originally isolated as an HIV-1 TAT-interactive protein, is known to interact with the viral TAT protein that leads to HTATIP polyubiquitination and targets it for degradation. It belongs to the MYST family of histone acetyltransferases (HATs). TIP60 is a catalytic subunit of the NuA4 HAT complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. A co-regulator of transcription factors, TIP60 either promotes or suppresses tumorigenesis. TIP60 is an enzyme that has a role in DNA repair and apoptosis and is thoμght to play an important role in signal transduction. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0014 | TIP60 Polyclonal Antibody | Inquiry |
| EAb-0015 | TIP60 Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1664 | TRIM24 (TIF1), GST-tag | Inquiry |
| PE-1667 | TRIM24 (TIF1), His-tag | Inquiry |
| PE-1887 | TIP60 (human recombinant) | Inquiry |
| Related Gene / Proteins | |||
| TIAL1 | TIEG1 | TIF1 | TIGD4 |
| TIGD5 | TIP49A | TIP49B | TIP60 |
| TIS11D | |||
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