| Cat.No.: | EAb-0012 |
| Product Name: | UHRF1 Polyclonal Antibody |
| Product Overview: | Polyclonal antibody to detect UHRF1 in human samples. |
| Antibody Type: | Polyclonal |
| Immunogen: | Recombinant protein of human UHRF1 |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | UHRF1 |
| Purification: | Affinity purified |
| Appearance: | Colorless liquid |
| Formulation: | 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3 |
| Applications: | Western blot, Immunohistochemistry, Immunoprecipitation, Immunofluorescene, CHIP |
| Recommended Dilutions/Conditions: |
Western blot: 1:500 – 1:2000, IHC: 1:50 – 1:200, IF: 1:20 – 1:50, IP: 1:20 – 1:50, CHIP: 1:20 – 1:50. Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Positive Control: | Western Blot: Various cell lysates |
| Species Reactivity: | Human |
| Shipping: | Gel Pack |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q96T88 |
| Alternative Name: | FLJ21925, ICBP90, MGC138707, Np95, RNF106, hNP95 |
| Scientific Background: | UHRF1, also named as ICBP90, NP95 and RNF106, is a putative E3 ubiquitin protein ligase. It may participate in methylation dependent transcriptional regulation. UHRF1 binds to inverted 5'CCAAT3' box 2 in the TOP2A promoter, and activates TOP2A expression. It is important for G1/S transition and may be involved in DNA repair and chromosomal stability. UHRF1's ability to repress its direct target gene expression is dependent on PHD (UHRF1) binding to unmodified H3R2. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0011 | UHRF2 Polyclonal Antibody | Inquiry |
| EAb-0012 | UHRF1 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0044 | Recombinant Human UHRF1 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0416 | Recombinant Human UHRF1 | Inquiry |
| PE-0417 | Recombinant Zebrafish UHRF1 | Inquiry |
| Related Gene / Proteins | |||
| UHRF1 | UHRF2 | ||
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