| Cat.No.: | EAb-0008 |
| Product Name: | USP2 Polyclonal Antibody |
| Product Overview: | Polyclonal antibody to detect USP2 (a DUB enzyme) in human, mouse and rat samples. |
| Antibody Type: | Polyclonal |
| Immunogen: | Fusion protein of human USP2 |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | USP2 |
| Purification: | Affinity purified |
| Appearance: | Colorless liquid |
| Formulation: | 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3 |
| Applications: | Western blot, Immunohistochemistry, Immunofluorescence |
| Recommended Dilutions/Conditions: |
Western blot: 1:200 – 1:500 dilution, IHC: 1:50 - 1:100 dilution. IF: 1:20 - 1:50 dilution. Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Positive Control: | Western Blot: Liver cell lysate |
| Species Reactivity: | Human, mouse, rat |
| Shipping: | Gel Pack |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | O75604 |
| Alternative Name: | USP2, UBP41, USP9 |
| Scientific Background: | Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzymes (DUB) action. There are five DUB subfamilies including the USP, UCH, OTU, MJD, and JAMM enzymes. Ubiquitinspecificprocessing protease 2 (USP2) belongs to the USP (UBP/UCH type 2) subfamily and is characterized by its C19 peptidase activity, which is involved in ubiquitin recycling and in the disassembly of various forms of polymeric ubiquitin and ubiquitin like protein complexes. There is mounting evidence that USP2 functions as an oncoprotein through multiple mechanisms. In human prostate cancer, USP2 is highly overexpressed and drives tumor growth by binding to and stabilizing fatty acid synthase through deubiquitination. It has also been demonstrated that USP2 can bind and deubiquitinate both Mdm2 and cyclin D1, which leads to their stabilization and enhanced cell proliferation. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0006 | USP3 Polyclonal Antibody | Inquiry |
| EAb-0007 | USP25 Polyclonal Antibody | Inquiry |
| EAb-0008 | USP2 Polyclonal Antibody | Inquiry |
| EAb-0009 | USP1 Polyclonal Antibody | Inquiry |
| EAb-0010 | USP7 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| USF1 | USP1 | USP10 | USP11 |
| USP12 | USP13 | USP14 | USP15 |
| USP16 | USP17L11 | USP17L12 | USP17L13 |
| USP17L15 | USP17L17 | USP17L1P | USP17L2 |
| USP17L22 | USP17L28 | USP17L3 | USP17L5 More > |
| USP17L8 | USP18 | USP19 | USP2 |
| USP20 | USP21 | USP22 | USP24 |
| USP25 | USP26 | USP27X | USP28 |
| USP29 | USP3 | USP30 | USP31 |
| USP32 | USP33 | USP34 | USP35 |
| USP36 | USP37 | USP38 | USP40 |
| USP42 | USP43 | USP44 | USP45 |
| USP46 | USP47 | USP48 | USP49 |
| USP5 | USP53 | USP54 | USP6 |
| USP6NL | USP7 | USP8 | USP9X |
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