| Cat.No.: | EAb-0002 |
| Product Name: | XRCC3 Polyclonal Antibody |
| Product Overview: | Polyclonal antibody to detect endogenous levels of XRCC3 in human, mouse and rat. |
| Antibody Type: | Polyclonal |
| Immunogen: | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human XRCC3 |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | XRCC3 |
| Purification: | Affinity purified |
| Appearance: | Colorless liquid |
| Formulation: | In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide |
| Applications: | WB, IH, IF/IC |
| Recommended Dilutions/Conditions: |
WB; 1:500 – 1:2000, IHC; 1:50 – 1:200, IF/IC; 1:50 – 1:100 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Positive Control: | WB: HeLa, mouse kidney, rat kidney lysates; IHC: human tonsil tissue; IFc: HeLa cell |
| Species Reactivity: | Human, Mouse, Rat |
| Shipping: | Gel Pack |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | O43542 |
| Alternative Name: | DNA repair protein XRCC3; X-ray repair cross-complementing protein 3 |
| Scientific Background: | Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0002 | XRCC3 Polyclonal Antibody | Inquiry |
| EAb-0299 | XRCC3 Polyclonal Antibody | Inquiry |
| EAb-1777 | XRCC1 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0456 | Human XRCC4 Knockout Cell Line 8bp deletion | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-2742 | Recombinant Human XRCC3 protein (denatured) | Inquiry |
| Related Gene / Proteins | |||
| XRCC1 | XRCC3 | XRCC4 | |
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