| Cat.No.: | BSM-0399 |
| Product Name: | (+)-JQ1 (free acid) |
| CAS No.: | 202592-23-2 |
| Figure: |
-JQ1 (free acid)-1.png)
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| Product Overview: | A selective inhibitor of BET bromodomains |
| Description: | (+)-JQ1 (free acid) is an inhibitor of bromodomain and extra terminal domain (BET) family proteins (Kds = 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively), blocking their interaction with acetylated histones. Enantiomerically pure (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively, whereas the(-)-JQ1 stereoisomer has no appreciable affinity to BET bromodomains. JQ1 has been used as a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 400.9 |
| Purity: | ≥98% |
| Storage: | -20°C |
| Targets: | BET bromodomains |
| Molecular Formula: | C19H17ClN4O2S |
| Chemical Name: | (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid |
| Warning: | For Research Use Only! Not For Use in Humans. |
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