| Cat.No.: | BSM-0342 |
| Product Name: | MS049 (hydrochloride) |
| CAS No.: | 2095432-59-8 |
| Figure: |
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| Product Overview: | A selective, dual PRMT4/PRMT6 inhibitor |
| Description: | MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 µM for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases or nonepigenetic targets tested. MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 µM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 321.3 |
| Purity: | ≥98% |
| Storage: | -20°C |
| Targets: | PRMT4; PRMT6 |
| Molecular Formula: | C15H24N2O • 2HCl |
| Chemical Name: | N-methyl-4-(phenylmethoxy)-1-piperidineethanamine, dihydrochloride |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0008 | PRMT4 peptide substrate, Biotin-labeled | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| BSM-0047 | SGC707 | Inquiry |
| ◆ Antibodies | ||
| EAb-0048 | PRMT6 Polyclonal Antibody | Inquiry |
| EAb-0049 | PRMT7 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| CABIN1 | CAF1 | CAMKIV | CAMTA2 |
| CAPNS2 | CARHSP1 | CARM1 | CASC3 |
| CASP | CASP1 | CASP3 | Pr-SET7 |
| PRC1 | PRC2 | PRDM1 | PRDM10 |
| PRDM11 | PRDM12 | PRDM13 | PRDM14 More > |
| PRDM15 | PRDM16 | PRDM17 | PRDM2 |
| PRDM3 | PRDM4 | PRDM5 | PRDM6 |
| PRDM7 | PRDM8 | PRDM9 | PREP1 |
| PRIM2 | PRKAA2 | PRKCA | PRKCB |
| PRKCE | PRKDC | PRKRIP1 | PRMT |
| prmt1 | PRMT2 | PRMT3 | PRMT5 |
| prmt6 | PRMT7 | PRMT8 | PRMT9 |
| Progerin | Protamine 2 | Prox1 | PRPF31 |
| PRPF40A | PRSS12 | PRSS55 | PRTFDC1 |
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