| Cat.No.: | BSM-0337 |
| Product Name: | BIIB021 |
| CAS No.: | 848695-25-0 |
| Figure: |
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| Synonyms: | CNF2024 |
| Product Overview: | A potent, orally-available Hsp90 inhibitor |
| Description: | BIIB021 is a potent, orally-available inhibitor of Hsp90 (Ki = 1.7 nM) that induces the degradation of oncoproteins, including HER2 (EC50 = 38 nM), while up-regulating the expression of Hsp70 and Hsp27. It is cytotoxic to cancer cells and, when administered orally to mice, inhibits growth of xenograft tumors. BIIB021 suppresses growth in various lymphoma cells but not in normal lymphocytes and induces apoptosis in a myelodysplastic syndrome cell line. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 318.8 |
| Purity: | ≥98% |
| Storage: | -20°C |
| Targets: | Hsp90 |
| Molecular Formula: | C14H15ClN6O |
| Chemical Name: | 6-chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0027 | Human HSPBAP1 Knockout Cell Line | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0337 | BIIB021 | Inquiry |
| ◆ Antibodies | ||
| EAb-1959 | HSC70 / HSP7C Monoclonal Antibody | Inquiry |
| EAb-1960 | HSP72 Monoclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-2336 | Recombinant Human HSPBAP1 protein | Inquiry |
| Related Gene / Proteins | |||
| HSC70 | HSF4 | HSP72 | Hsp90 |
| HSPBAP1 | hSSB1 | ||
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