| Cat.No.: | BSM-0331 |
| Product Name: | MS37452 |
| CAS No.: | 423748-02-1 |
| Figure: |
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| Product Overview: | An inhibitor of CBX7 chromodomain binding to H3K27me3 |
| Description: | Chromobox homolog 7 (CBX7) functions through its N-terminal chromodomain, which recognizes histone 3 trimethyl lysine 27 (H3K27me3), to repress gene transcription. It plays a key role in gene transcription in cellular processes related to stem cell self-renewal and differentiation, as well as tumor progression. MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM). At 250 µM, it has been shown to derepress transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 398.5 |
| Purity: | ≥98% |
| Storage: | -20°C |
| Targets: | CBX7 chromodomain binding to H3K27me3 |
| Molecular Formula: | C22H26N2O5 |
| Chemical Name: | 1-[4-(2,3-dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0053 | Human CBX5 Knockout Cell Line 2bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0146 | CBX5 Polyclonal Antibody | Inquiry |
| EAb-0148 | CBX3 Polyclonal Antibody | Inquiry |
| EAb-0150 | CBX2 Polyclonal Antibody | Inquiry |
| EAb-0153 | CBFb Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| CBFb | CBX2 | CBX3 | CBX4 |
| CBX5 | CBX6 | CBX7 | CBX8 |
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