| Cat.No.: | BSM-0324 |
| Product Name: | UNC2170 (maleate) |
| Figure: |
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| Product Overview: | A 53BP1 antagonist |
| Description: | p53-Binding protein 1 (53BP1) binds to dimethylated lysine 20 on histone 4 (H4K20me2) via tandem tudor domains on a 53BP1 homodimer. This interaction is an important part of the DNA damage response. UNC2170 is a micromolar ligand of 53BP1 that binds to a pocket formed by the tandem tudor domains. It displays at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. UNC2170 functions as a 53BP1 antagonist in cellular lysates and shows cellular activity by suppressing class switch recombination, a process which requires a functional 53BP1 tudor domain. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 429.3 |
| Purity: | ≥95% |
| Storage: | -20°C |
| Targets: | p53-Binding protein 1 (53BP1) |
| Molecular Formula: | C14H21BrN2O • C4H4O4 |
| Chemical Name: | 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]-benzamide, 2Z-butenedioate |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0013 | TP2 Polyclonal Antibody | Inquiry |
| EAb-0623 | p53 Monoclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0053 | UNC-2170 | Inquiry |
| BSM-0324 | UNC2170 (maleate) | Inquiry |
| ◆ Cell Lines | ||
| CL-0438 | Human TP53BP1 Knockout Cell Line 40bp deletion | Inquiry |
| Related Gene / Proteins | |||
| TP2 | TP53BP1 | ||
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