| Cat.No.: | BSM-0322 |
| Product Name: | BVT 948 |
| CAS No.: | 39674-97-0 |
| Figure: |
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| Product Overview: | An inhibitor of protein tyrosine phosphatases |
| Description: | BVT 948 is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTP; IC50s = 0.09-1.7 µM). It facilitates the oxidation of the catalytic cysteine residue by hydrogen peroxide. Similarly, it inhibits redox-sensitive cytochrome P450 (CYP) isoforms, including CYP2C19 and CYP2D6, with IC50 values less than 10 µM. BVT 948 also inhibits the protein methyltransferases SETD8, SETD2, G9a, SMYD2, CARM1, and PRMT3 with IC50 values from 0.7 to 3.2 µm. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 241.2 |
| Purity: | ≥98% |
| Storage: | -20°C |
| Targets: | Protein tyrosine phosphatases; protein methyltransferases |
| Molecular Formula: | C14H11NO3 |
| Chemical Name: | 4-hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0008 | PRMT4 peptide substrate, Biotin-labeled | Inquiry |
| ◆ Antibodies | ||
| EAb-0019 | SMARCA4 Polyclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0025 | BIX01294 (hydrochloride hydrate) | Inquiry |
| BSM-0026 | UNC0224 | Inquiry |
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
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