| Cat.No.: | BSM-0308 |
| Product Name: | JFD00244 |
| CAS No.: | 96969-83-4 |
| Figure: |
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| Synonyms: | BML-266 |
| Product Overview: | An inhibitor of SIRT2 |
| Description: | Human sirtuin 2 (SIRT2) is a NAD+-dependent protein deacetylase with diverse targets, including α-tubulin, phosphoenolpyruvate carboxykinase, and forkhead box protein O1. JFD00244 is an inhibitor of SIRT2 (IC50= 56.7 µM). At 5 µM, JFD00244 induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 478.5 |
| Purity: | ≥95% |
| Storage: | -20°C |
| Targets: | SIRT2 |
| Molecular Formula: | C30H26N2O4 |
| Chemical Name: | 1,4-bis[[2-(4-hydroxyphenyl)ethyl]amino]-9,10-anthracenedione |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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