| Cat.No.: | BSM-0307 |
| Product Name: | I-CBP112 (hydrochloride) |
| CAS No.: | 2147701-33-3 |
| Figure: |
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| Product Overview: | A selective inhibitor of CBP and EP300 |
| Description: | cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators that modulate DNA replication, DNA repair, cell growth, transformation, and development. Both CBP and EP300 contain bromodomains, which mediate their binding to acetylated lysine residues on histones and other proteins. I-CBP112 is a selective inhibitor of CBP and EP300 that directly binds their bromodomains (Kds = 0.142 and 0.625 μM, respectively). |
| Appearance: | A crystalline solid |
| Molecular Weight: | 505.1 |
| Purity: | ≥90% |
| Storage: | -20°C |
| Targets: | CBP; EP300 |
| Molecular Formula: | C27H36N2O5 • HCl |
| Chemical Name: | 1-[7-(3,4-dimethoxyphenyl)-2,3-dihydro-9-[[(3S)-1-methyl-3-piperidinyl]methoxy]-1,4-benzoxazepin-4(5H)-yl]-1-propanone, monohydrochloride |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0038 | CTPB | Inquiry |
| BSM-0073 | Anacardic Acid | Inquiry |
| BSM-0094 | C646 | Inquiry |
| ◆ Cell Lines | ||
| CL-0055 | Human CREBBP Knockout Cell Line 1bp insertion | Inquiry |
| CL-0061 | Human EP300 Knockout Cell Line 13bp deletion | Inquiry |
| Related Gene / Proteins | |||
| CREB | CREB3 | crebbp | CRISP1 |
| CRISP3 | CRP | EP300 | EPC1 |
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