| Cat.No.: | BSM-0301 |
| Product Name: | Lysine-specific Demethylase Inhibitor (1C) (hydrochloride) |
| CAS No.: | 1234494-75-7 |
| Figure: |
 (hydrochloride)-1.png)
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| Synonyms: | KDM1 Inhibitor I; LSD Inhibitor I |
| Product Overview: | An LSD1 inhibitor |
| Description: | Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4). LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used at a concentration of 10 µM. It increases the level of H3K4 methylation, including H3K4me1 and H3K4me2 but not H3K9me2 levels, in HCT116 human colon carcinoma cells. LSD inhibitor (1C) also induces re-expression of the Wnt signaling pathway proteins secreted frizzle-related protein 1 (SFRP1), SFRP4, and SFRP5, as well as the transcription factor GATA5, which are aberrantly silenced in HCT116 cells. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 474.3 |
| Purity: | ≥95% |
| Storage: | Room temperature |
| Targets: | LSD1 |
| Molecular Formula: | C15H36N8 • 4HCl |
| Chemical Name: | N1,N1,N15,N15-tetramethyl-2,6,10,14-tetraazapentadecanediimidamide, tetrahydrochloride |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Research Kits | ||
| EKIT-0062 | Histone Demethylase LSD1 Activity/Inhibition Assay Kit | Inquiry |
| EKIT-0126 | LSD1 Inhibitor Screening Assay Kit | Inquiry |
| EKIT-0160 | LSD1 Demethylase Activity/Inhibition Fluorometric Assay Kit | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0111 | DDP-38003 dihydrochloride | Inquiry |
| BSM-0141 | GSK-LSD1 dihydrochloride | Inquiry |
| Related Gene / Proteins | |||
| LSD1 | LSD2 | LSM2 | LSM3 |
| LSM5 | LSM6 | LSP1 | |
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