| Cat.No.: | BSM-0295 |
| Product Name: | GSK-J1 (sodium salt) |
| CAS No.: | 1797832-71-3 |
| Figure: |
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| Product Overview: | A dual inhibitor of JMJD3 and UTX |
| Description: | GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 and UTX. It is inactive against a panel of additional JMJ family demethylases, including several variants of JMJD2 and JMJD1 and, at concentrations up to 30 μM, has no effect on more than 100 different kinases or other unrelated proteins, including other chromatin-modifying enzymes such as histone deacetylases. Since the highly polar carboxylate group of GSK-J1 restricts its cellular permeability, a prodrug ethyl ester, GSK-J4 has also been developed. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 411.4 |
| Purity: | ≥95% |
| Storage: | -20°C |
| Targets: | JMJD3; UTX |
| Molecular Formula: | C22H22N5O2 • Na |
| Chemical Name: | N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine, monosodium salt |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0072 | JMJD6 Polyclonal Antibody | Inquiry |
| EAb-0074 | JMJD2c Polyclonal Antibody | Inquiry |
| EAb-0075 | JMJD2b Polyclonal Antibody | Inquiry |
| EAb-0076 | JMJD2A Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JMJD | JMJD1A | JMJD1B | JMJD1C |
| JMJD2 | JMJD2A | JMJD2B | JMJD2C |
| JMJD2D | JMJD2E | JMJD2F | JMJD3 |
| JMJD4 | JMJD5 | JMJD6 | UTF1 |
| UTX | |||
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